Clonal distribution and associated characteristics of Escherichia coli clinical and surveillance isolates from a military medical center

Amee R. Manges, Katrin Mende, Clinton K. Murray, Brian D. Johnston, Evgeni V. Sokurenko, Veronika Tchesnokova, James R. Johnson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Antimicrobial-resistant Escherichia coli are a concern for military health services. We studied 100 extended-spectrum beta-lactamase (ESBL)-producing and non-producing E. coli clinical and surveillance isolates from military personnel and civilians at Brooke Army Medical Center (2007–2011). Major E. coli lineages, most prominently ST10 (24%), ST131 (16%), and ST648 (8%), were distributed much as reported for other North American populations. ST131, represented mainly by its resistance-associated ST131-H30 clonal subset, was uniquely associated with a clinical origin, regardless of ESBL status. Thus, clonal background predicted resistance phenotype and clinical versus surveillance origin, and these findings could assist military clinicians and epidemiologists.

Original languageEnglish (US)
Pages (from-to)382-385
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume87
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Antimicrobial resistance
  • Escherichia coli infections
  • Extended-spectrum beta-lactamases
  • Military medicine
  • Molecular epidemiology
  • Multilocus sequence typing
  • ST131
  • ST131-H30
  • Veterans
  • Virulence genes

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