Clustering of cardiovascular risk factors in hyperinsulinemia in Japanese without diabetes

Hisashi Adachi, David R. Jacobs, Ryuichi Hashimoto, Makoto Tsuruta, Tsutomu Imaizumi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Clustering of cardiovascular risk factors in hyperinsulinemia was investigated in 247 Japanese subjects without diabetes. After adjustment for age and sex, the highest quartile of the summed values of insulin concentrations after oral glucose loading showed high odds ratios (OR; 95% confidence intervals) for the prevalence of cardiovascular risk factors: OR = 2.02 (1.07-3.83) for hypertension, 3.91 (1.82-8.40) for hypertriglyceridemia, 2.41 (1.30-4.46) for low high-density lipoprotein cholesterol, 2.41 (1.28- 4.51) for impaired glucose tolerance, and 3.58 (1.44-8.88) for high uric acid. Two or more of these factors were clinically elevated in 50% of those in the highest quartile of the summed values of insulin, compared to 16-28% of those in the lower three quartiles. These findings were slightly attenuated after further adjustment for body mass index and sum of skinfolds. In conclusion, multiple risk factors for cardiovascular disease existed in the subjects with hyperinsulinemia in Japanese without diabetes.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalDiabetes Research and Clinical Practice
Volume40
Issue number3
DOIs
StatePublished - Jun 1998

Bibliographical note

Funding Information:
We are grateful to members of the Japan Medical Association of Ukiha, the elected officials and residents of Tanushimaru, and our team physicians and senior members of The Third Department of Internal Medicine, Kurume University School of Medicine, for their help in carrying out the medical examinations. This study was supported in part by the Kimura Memorial Heart Foundation, Fukuoka, Japan.

Keywords

  • Cardiovascular disease
  • Hyperinsulinemia
  • Multiple risk factors

Fingerprint Dive into the research topics of 'Clustering of cardiovascular risk factors in hyperinsulinemia in Japanese without diabetes'. Together they form a unique fingerprint.

Cite this