TY - JOUR
T1 - Co-Stimulatory functions of antigen-presenting cells
AU - Johnson, Julia G.
AU - Jenkins, Marc
PY - 1992/11
Y1 - 1992/11
N2 - Antigen-presenting cells, in addition to presenting processed antigen, provide co-stimulatory signals that are necessary for stimulating maximal lymphokine production by CD4+ T cells. For interleukin 2 (IL-2) - producing CD4+ T cells, the B7 molecule provides an important co-stimulatory signal through interaction with its ligand on the T-cell surface, CD28. Populations of antigen-presenting cells that express high levels of B7 (e.g., dendritic cells) are much more potent stimulators of T-cell activation than cells that fail to express B7 (e.g., resting B cells). An increase in B7 expression could therefore explain the increased accessory function gained by Langerhans cells as they leave the skin and migrate to the draining lymph node. J Invest Dermatol 99: 62S- 65S, 1992.
AB - Antigen-presenting cells, in addition to presenting processed antigen, provide co-stimulatory signals that are necessary for stimulating maximal lymphokine production by CD4+ T cells. For interleukin 2 (IL-2) - producing CD4+ T cells, the B7 molecule provides an important co-stimulatory signal through interaction with its ligand on the T-cell surface, CD28. Populations of antigen-presenting cells that express high levels of B7 (e.g., dendritic cells) are much more potent stimulators of T-cell activation than cells that fail to express B7 (e.g., resting B cells). An increase in B7 expression could therefore explain the increased accessory function gained by Langerhans cells as they leave the skin and migrate to the draining lymph node. J Invest Dermatol 99: 62S- 65S, 1992.
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U2 - 10.1111/1523-1747.ep12669010
DO - 10.1111/1523-1747.ep12669010
M3 - Article
C2 - 1358981
AN - SCOPUS:0026486531
SN - 0022-202X
VL - 99
SP - 62
EP - 65
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -