TY - JOUR
T1 - Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways)
AU - Smith, Rachel J.
AU - Lobo, Mary Kay
AU - Spencer, Sade
AU - Kalivas, Peter W.
N1 - Funding Information:
This work was funded by National Institutes of Health grants R01 DA03906 , R01 DA12513 , and P50 DA015369 (PWK), and F32 DA031519 (RJS).
PY - 2013/8
Y1 - 2013/8
N2 - Cocaine exposure causes enduring neuroadaptations in ventral striatum, or nucleus accumbens (NAc), an area critically involved in reward learning and relapse of drug seeking. Medium spiny neurons (MSNs) in striatum are dichotomous in their expression of either D1 or D2 dopamine receptors, along with other receptors and neuropeptides. In dorsal striatum, these two subpopulations show non-overlapping innervation of distinct terminal fields via the direct or indirect pathways. However, NAc D1-MSNs and D2-MSNs are not fully segregated in this manner, with both cell types innervating ventral pallidum. Recent studies show that D1-MSNs and D2-MSNs play opposing roles in cocaine-associated behaviors. Further, cocaine induces differential adaptations in these two subpopulations in NAc, including changes to synaptic plasticity, glutamatergic signaling, and spine morphology.
AB - Cocaine exposure causes enduring neuroadaptations in ventral striatum, or nucleus accumbens (NAc), an area critically involved in reward learning and relapse of drug seeking. Medium spiny neurons (MSNs) in striatum are dichotomous in their expression of either D1 or D2 dopamine receptors, along with other receptors and neuropeptides. In dorsal striatum, these two subpopulations show non-overlapping innervation of distinct terminal fields via the direct or indirect pathways. However, NAc D1-MSNs and D2-MSNs are not fully segregated in this manner, with both cell types innervating ventral pallidum. Recent studies show that D1-MSNs and D2-MSNs play opposing roles in cocaine-associated behaviors. Further, cocaine induces differential adaptations in these two subpopulations in NAc, including changes to synaptic plasticity, glutamatergic signaling, and spine morphology.
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U2 - 10.1016/j.conb.2013.01.026
DO - 10.1016/j.conb.2013.01.026
M3 - Review article
C2 - 23428656
AN - SCOPUS:84881115602
SN - 0959-4388
VL - 23
SP - 546
EP - 552
JO - Current opinion in neurobiology
JF - Current opinion in neurobiology
IS - 4
ER -