Cochlear fluid balance: A clinical/research overview

Arndt J. Duvall, Peter A. Santi, Margaret J. Hukee

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Stria edema, and in some cases atrophy, follows osmotic agents, loop-inhibiting diuretics, acoustic trauma, and rupture of Reissner's membrane. All have in common an imbalance of fluid and electrolytes in the cochlear duct. The glycerol test causes temporary improvement in hearing in Menière's disease. Glycerol causes stria edema and collapse of Reissner's membrane in the chinchilla. Stria edema, as well as stria atrophy, are found in Menière's disease. Metabolic manipulation of the stria might be the best approach in the search for successful treatment of Menière's disease.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalAnnals of Otology, Rhinology & Laryngology
Issue number4
StatePublished - Jul 1980

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