Coffee and tea consumption in the early adult lifespan and left ventricular function in middle age: the CARDIA study

Chike C. Nwabuo, Aisha S. Betoko, Jared P. Reis, Henrique T. Moreira, Henrique D. Vasconcellos, Eliseo Guallar, Christopher Cox, Stephen Sidney, Bharath Ambale-Venkatesh, Cora E. Lewis, Pamela J. Schreiner, Donald Lloyd-Jones, Catarina I. Kiefe, Samuel S. Gidding, João A.C. Lima

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: The long-term impact of coffee or tea consumption on subclinical left ventricular (LV) systolic or diastolic function has not been previously studied. We examined the association between coffee or tea consumption beginning in early adulthood and cardiac function in midlife. Methods and results: We investigated 2735 Coronary Artery Risk Development in Young Adults (CARDIA) study participants with long-term total caffeine intake, coffee, and tea consumption data from three visits over a 20 year interval and available echocardiography indices at the CARDIA Year-25 exam (2010–2011). Linear regression models were used to assess the association between caffeine intake, tea, and coffee consumption (independent variables) and echocardiography outcomes [LV mass, left atrial volume, and global longitudinal strain (GLS), LV ejection fraction (LVEF), and transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity (E/e´)]. Models were adjusted for standard cardiovascular risk factors, socioeconomic status, physical activity, alcohol use, and dietary factors (calorie intake, whole and refined grain intake, and fruit and vegetable consumption). Mean (standard deviation) age was 25.2 (3.5) years at the CARDIA Year-0 exam (1985–1986), 57.4% were women, and 41.9% were African-American. In adjusted multivariable linear regression models assessing the relationship between coffee consumption and GLS, beta coefficients when comparing coffee drinkers of <1, 1–2, 3–4, and >4 cups/day with non-coffee drinkers were β = −0.30%, P < 0.05; β = −0.35%, P < 0.05; β = −0.32%, P < 0.05; β = −0.40%, P > 0.05; respectively (more negative values implies better systolic function). In adjusted multivariable linear regression models assessing the relationship between coffee consumption and E/e´, beta coefficients when comparing coffee drinkers of <1, 1–2, 3–4, and >4 cups/day with non-coffee drinkers were β = −0.29, P < 0.05; β = −0.38, P < 0.01; β = −0.20, P >.05; and β = −0.37, P > 0.05, respectively (more negative values implies better diastolic function). High daily coffee consumption (>4 cups/day) was associated with worse LVEF (β = −1.69, P < 0.05). There were no associations between either tea drinking or total caffeine intake and cardiac function (P > 0.05 for all). Conclusions: Low-to-moderate daily coffee consumption from early adulthood to middle age was associated with better LV systolic and diastolic function in midlife. High daily coffee consumption (>4cups/day) was associated with worse LV function. There was no association between caffeine or tea intake and cardiac function.

Original languageEnglish (US)
Pages (from-to)1510-1519
Number of pages10
JournalESC Heart Failure
Volume7
Issue number4
DOIs
StatePublished - Aug 1 2020

Bibliographical note

Funding Information:
The CARDIA is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I and HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). This manuscript has been reviewed by the CARDIA study for scientific content.

Keywords

  • Coffee
  • Left ventricle
  • Left ventricular function
  • Tea
  • caffeine

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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