Cognitive Therapy and Pharmacotherapy for Depression: Singly and in Combination

Steven D. Hollon, Robert J. Derubeis, Mark D. Evans, Marlin J. Wiemer, Michael J. Garvey, William M Grove, Vicente B. Tuason

Research output: Contribution to journalArticlepeer-review

405 Scopus citations

Abstract

Cognitive therapy and imipramine hydrochloride tricyclic pharmacotherapy, each singly and in combination, were compared in the treatment of nonpsychotic, nonbipolar depressed outpatients. One hundred seven patients were randomly assigned to 12 weeks of active treatment; 64 patients completed the full course of treatment. Rates of attrition were high but not differential. Cognitive therapy and pharmacotherapy did not differ in terms of symptomatic response, either in the primary analyses or in secondary analyses restricted to more severely depressed outpatients. Initial severity did predict response within pharmacotherapy alone, but not within cognitive therapy. Combining cognitive therapy with pharmacotherapy did not markedly improve response over that observed for either modality alone, although such nonsignificant differences as were evident did favor the combined treatment. Two patients died as a consequence of suicide attempts, both of which involved study medication.

Original languageEnglish (US)
Pages (from-to)774-781
Number of pages8
JournalArchives of General Psychiatry
Volume49
Issue number10
DOIs
StatePublished - Oct 1992

Fingerprint Dive into the research topics of 'Cognitive Therapy and Pharmacotherapy for Depression: Singly and in Combination'. Together they form a unique fingerprint.

Cite this