Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV

Jack T. Stapleton; Henry H. Balfour

doi:10.1016/j.chom.2008.08.006

Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV

Jack T. Stapleton, Henry H. Balfour

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.

Original language	English (US)
Pages (from-to)	194-195
Number of pages	2
Journal	Cell Host and Microbe
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2008.08.006
State	Published - Sep 11 2008

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title = "Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV",

abstract = "The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.",

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Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV

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