Cold agglutinins in infectious mononucleosis and heterophil antibody negative mononucleosis like syndromes

C. A. Horwitz, J. Moulds, W. Henle, G. Henle, H. Polesky, H. H. Balfour, B. Schwartz, T. Hoff

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophilpositive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in <1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalUnknown Journal
Volume50
Issue number2
DOIs
StatePublished - 1977

Fingerprint Dive into the research topics of 'Cold agglutinins in infectious mononucleosis and heterophil antibody negative mononucleosis like syndromes'. Together they form a unique fingerprint.

Cite this