Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

Lisa A. Kroeger; Laurie B. Hovde; Isaac F. Mitropoulos; Jeremy Schafer; John C Rotschafer

doi:10.1128/AAC.01433-06

Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

Lisa A. Kroeger, Laurie B. Hovde, Isaac F. Mitropoulos, Jeremy Schafer, John C Rotschafer

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.

Original language	English (US)
Pages (from-to)	3431-3433
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	9
DOIs	https://doi.org/10.1128/AAC.01433-06
State	Published - Sep 2007

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abstract = "Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.",

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AU - Schafer, Jeremy

AU - Rotschafer, John C

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AB - Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.

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Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

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