Collision tumor versus multiphenotypic differentiation: A case of carcinoma with features of colonic and lung primary tumors

Pradeep Murthaiah, Alexander M. Truskinovsky, Saira Shah, Arkadiusz Z. Dudek

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background: Collision tumors are rare tumors composed of two histologically distinct neoplasms coinciding at the same location. Collision tumors need to be distinguished from tumors originating from a progenitor cell with potential for multiphenotypic differentiation. Case Report: A clinically puzzling case of an intricate malignant pulmonary nodule in a patient with previous history of colorectal carcinoma is reported. A brief review of the clinical literature on collision tumor and tumor stem cells is presented. Conclusion: This case report emphasizes the importance of detailed histopathologic and immunohistochemical analyses, and clinical history in diagnosing a tumor composed of multiple malignant morphologies.

Original languageEnglish (US)
Pages (from-to)1495-1497
Number of pages3
JournalAnticancer Research
Volume29
Issue number5
StatePublished - May 1 2009

Keywords

  • Adenocarcinoma of the colon
  • Collision tumor
  • Non-small cell lung cancer
  • Tumor stem cell

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