Colonoscopic screening shows increased early incidence and progression of adenomas in cystic fibrosis

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Abstract

Background Colorectal cancer is an emerging problem in cystic fibrosis (CF). The goal of this study was to evaluate adenoma detection by systematic colonoscopic screening and surveillance. Methods We analyzed prospectively collected results of colonoscopies initiated at age 40 years from 88 CF patients at a single Cystic Fibrosis Center. We also reviewed results of diagnostic colonoscopies from 27 patients aged 30–39 years performed during the same time period at the Center. Results The incidence of polyp detection increased markedly after age 40 in CF patients. Greater than 50% were found to have adenomatous polyps; approximately 25% had advanced adenomas as defined by size and/or histopathology; 3% were found to have colon cancer. Multivariate analysis demonstrated specific risk factors for adenoma formation and progression. Conclusions Early screening and more frequent surveillance should be considered in patients with CF due to early incidence and progression of adenomas in this patient population.

Original languageEnglish (US)
Pages (from-to)548-553
Number of pages6
JournalJournal of Cystic Fibrosis
Volume15
Issue number4
DOIs
StatePublished - Jul 1 2016

Bibliographical note

Funding Information:
Grant Support. Funding for this work included a Seed Grant from the University of Minnesota Academic Health Center (AK; AHC Seed Grant 2010 ) and Cystic Fibrosis Foundation grant (DEN).

Publisher Copyright:
© 2016 European Cystic Fibrosis Society.

Keywords

  • Adenoma
  • Colon cancer
  • Colorectal cancer screening
  • Cystic fibrosis

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