TY - JOUR
T1 - Colorimetric monitoring of solid-phase aldehydes using 2,4- dinitrophenylhydrazine
AU - Shannon, Simon K.
AU - Barany, George
PY - 2004/3
Y1 - 2004/3
N2 - A simple and rapid method to achieve colorimetric monitoring of resin-bound aldehydes, based on ambient temperature reaction with 2,4-dinitrophenylhydrazine (DNPH) in the presence of dilute acid, has been developed as an adjunct to solid-phase organic synthesis and combinatorial chemistry. By this test, the presence of aldehydes is indicated by a red to dark-orange appearance, within a minute. Alternatively, resins that are free of aldehydes or in which aldehyde functions have reacted completely retain their original color. The DNPH test was demonstrated for poly(ethylene glycol)-polystyrene (PEG-PS), aminomethyl polystyrene (AMP), cross-linked ethoxylate acrylate resin (CLEAR), and acryloylated O,O′-bis(2- aminopropyl)poly-(ethylene glycol) (PEGA) supports and gave results visible to the naked eye at levels as low as 18 μmol of aldehyde per gram of resin.
AB - A simple and rapid method to achieve colorimetric monitoring of resin-bound aldehydes, based on ambient temperature reaction with 2,4-dinitrophenylhydrazine (DNPH) in the presence of dilute acid, has been developed as an adjunct to solid-phase organic synthesis and combinatorial chemistry. By this test, the presence of aldehydes is indicated by a red to dark-orange appearance, within a minute. Alternatively, resins that are free of aldehydes or in which aldehyde functions have reacted completely retain their original color. The DNPH test was demonstrated for poly(ethylene glycol)-polystyrene (PEG-PS), aminomethyl polystyrene (AMP), cross-linked ethoxylate acrylate resin (CLEAR), and acryloylated O,O′-bis(2- aminopropyl)poly-(ethylene glycol) (PEGA) supports and gave results visible to the naked eye at levels as low as 18 μmol of aldehyde per gram of resin.
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U2 - 10.1021/cc034033x
DO - 10.1021/cc034033x
M3 - Article
C2 - 15002963
AN - SCOPUS:1842506704
SN - 1520-4766
VL - 6
SP - 165
EP - 170
JO - Journal of Combinatorial Chemistry
JF - Journal of Combinatorial Chemistry
IS - 2
ER -