Colostral antibody-mediated and cell-mediated immunity contributes to innate and antigen-specific immunity in piglets

Meggan Bandrick, Claudia Ariza-Nieto, Samuel K Baidoo, Thomas W Molitor

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Immunoglobulins and immune cells are critical components of colostral immunity; however, their transfer to and function in the neonate, especially maternal lymphocytes, is unclear. Cell-mediated and antibody-mediated immunity in sow blood and colostrum and piglet blood before (PS) and after (AS) suckling were assessed to investigate transfer and function of maternal immunity in the piglet. CD4, CD8, and γδ lymphocytes were found in sow blood and colostrum and piglet blood PS and AS; each had a unique T lymphocyte profile. Immunoglobulins were detected in sow blood, colostrum, and in piglet blood AS; the immunoglobulin profile of piglet serum AS mimicked that of sow serum. These results suggest selectivity in lymphocyte concentration into colostrum and subsequent lymphocyte transfer into the neonate, but that immunoglobulin transfer is unimpeded. Assessment of colostral natural killer activity and antigen-specific proliferation revealed that colostral cells are capable of influencing the innate and specific immune response of neonatal pigs.

Original languageEnglish (US)
Pages (from-to)114-120
Number of pages7
JournalDevelopmental and Comparative Immunology
Volume43
Issue number1
DOIs
StatePublished - Mar 2014

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Colostrum
  • Maternally derived immunity
  • Neonate
  • Passive transfer
  • Swine
  • T lymphocyte

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