Combining engineering and evolution to create novel metabolic mutualisms between species

Lon Chubiz, Sarah Douglas, William Harcombe

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Synthetic communities can be used as model systems for the molecular examination of species interactions. Manipulating synthetic communities to create novel beneficial interactions provides insight into the mechanisms of cooperation as well as the potential to improve the productivity of industrially relevant systems. Here, we present a general scheme for evolving a mutualism from a bacterial consortium in which one species consumes the by-products of another.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalMethods in Molecular Biology
Volume1151
DOIs
StatePublished - Jan 1 2014

Keywords

  • Consortia
  • Cooperation
  • Cross-feeding
  • Evolution
  • Synthetic ecology

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