Common genetic variants in the 8q24 region and risk of papillary thyroid cancer

Gila Neta, Chu Ling Yu, Alina Brenner, Fangyi Gu, Amy Hutchinson, Ruth Pfeiffer, Erich M. Sturgis, Li Xu, Martha S. Linet, Bruce H. Alexander, Stephen Chanock, Alice J. Sigurdson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objectives/Hypothesis: Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome-wide scans have been associated with the risk of several cancers, including breast (rs1562430), prostate (rs1447295), and colon (rs6983267). A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to the risk of sporadic PTC. Study Design: Case-control study. Methods: We evaluated 157 tag SNPs in the 8q24 chromosomal region between 120.91 Mb and 128.78 Mb (including rs1562430, rs1447295, and rs6983267) in a case-control study of 344 PTC cases and 452 age and gender frequency-matched controls. We used logistic regression to estimate odds ratios and compute P values of linear trend for PTC with genotypes of interest. To account for multiple comparisons, we applied the false discovery rate (FDR) method. Results: We did not find a significant association between rs1562430, rs1447295, or rs6983267 and PTC risk. We found that one SNP (rs4733616) was associated with PTC risk at P =.003, and 12 other SNPs were associated with PTC risk at P <.05. However, no SNPs remained significant after FDR correction. Conclusions: Our findings do not support a strong association between SNPs in the 8q24 chromosomal region and risk of sporadic PTC, but several SNPs with small effects might exist.

Original languageEnglish (US)
Pages (from-to)1040-1042
Number of pages3
JournalLaryngoscope
Volume122
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • 8q24
  • single nucleotide polymorphisms
  • thyroid cancer

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