Comparative analysis of staphylococcal adhesion and internalization by epithelial cells

Xudong Liang, Yinduo Ji

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Multiple drug resistance to antibiotics is a major public health problem. Many mechanisms may be involved in such resistance. Increasing data have shown that Staphylococcus aureus can invade different types of nonphagocytic cells, which, in turn, may contribute to evasion of the toxicity of certain antibiotics. The fibronectin-binding proteins are required for S. aureus to adhere to and internalize into the host cells. We have shown that a twocomponent signal transduction system, SaeRS, is essential for bacterial adhesion and invasion of the epithelial cells.

Original languageEnglish (US)
Title of host publicationMethicillin-Resistant Staphylococcus aureus (MRSA) Protocols
Pages145-151
Number of pages7
DOIs
StatePublished - Oct 1 2007

Publication series

NameMethods in Molecular Biology
Volume391
ISSN (Print)1064-3745

Keywords

  • Adhesion
  • Cells
  • Human epithelial
  • Invasion
  • Staphylococcus aureus

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