Comparative carcinogenicity in f344 rats of the tobacco-specific nitrosamines, n’-nitrosonornicotine and 4-(n-methyl-n-nitrosamino)-1 -(3-pyridyl)-1 -butanone

Stephen S. Hecht, Chi Hong B. Chen, Takaaki Ohmori, Dietrich Hoffmann

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167 Scopus citations

Abstract

The tobacco-specific carcinogens, N’-nitrosonornicotine (NNN) and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyI)-1-butanone (NNK), were tested for carcinogenicity in F344 rats. Each nitrosamine in trioctanoin was administered by s.c. injection to 12 male and 12 female rats over a period of 20 weeks. The total dose of each nitrosamine was 3.4 mmol. The experiment was terminated after 12 months. NNK induced nasal cavity tumors in 83% of the males and in 83% of the females, liver tumors in 83% of the males and in 100% of the females, and lung tumors in 67% of the males and in 67% of the females. NNN induced nasal cavity tumors in 92% of the males and in 75% of the females. Only one liver tumor and no lung tumors were observed in the NNN-treated rats. These results indicate that, in the F344 rat, NNK is a more powerful carcinogen than is NNN.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
JournalCancer Research
Volume40
Issue number2
StatePublished - Feb 1 1980

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