Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure

Jay Cohn; Morton Hawkins; Herbert Levine; John Naughton; Elliot Rapaport; Sidney Goldstein; Bertram Pitt; Sidney Goldstein; Robert Cody; Prakash Deedwania; Leonard Dennick; Joseph Franciosa; Mark Mcgovern; Joseph Meyer; Bertram Pitt; Joseph Franciosa; Sidney Goldstein; Robert Cody; Prakash Deedwania; Alan Gradman; Barry Massie; Milton Packer; James Doherty; Jacquelyn Gammill; William Cooper; Stanford Engel; Rita Fand; Barbara Hallows; Linda Kerwin; Debra A. Soltesz; John O. Parker; Karen Lahey; Prakash C. Deedwania; Enrique Carbajal; Pat Watson; Robert Dibianco; James A. Ronan; Dennis J. Donohue; Keith M. Lindgren; Louis J. Larca; Judy Freitag; Donna Lindemuth; Jeffrey B. Lakier; Howard S. Rosman; Mary Beth Wlodkowski; Robert J. Cody; Spencer H. Kubo; Mary Clark; Katie Pondolfino; Joseph A. Franciosa; Mary Wilen; Drexel Jordan; Sunil K. Das; John M. Nicklas; Mary Kay Foley; Michael B. Higginbotham; Frederick R. Cobb; Jean Wilson; David M. Berkson; Dragic Obradovic; Patricia Hershinow; N. Gary Nicholls; Hamid Ikram; Ian Crozier; Carl J. Pepine; John Culp; Marion Limacher; Kathy Mulvehill Verbust; D. John Farnham; Dorothy Adams; Norene Streicher; Carol Shanley; Mark A. Greenberg; Janet Strain; Mary Hewitt; Barbara Levine; D. Norman Sharpe; Robin Briant; Rene Coxon; Barry M. Massie; James W. Cornyn; Nina Topic; Harold Willens; Denise Antonishen; Dorothy Reinstein; Harry Colfer; Karen E. Graham; Gerald M. Perlow; Harvey S. Zarren; Barbara Bent; Marjorie Zicherman; Alan Gradman; Barry Zaret; Deborah Lawrason; Pat Tellier; Kathy O’keefe; Syed Mohiuddin; Lois Stengel; James D. Madison; Nancy Carruthers; Milton Packer; Fernando Elijovich; Mary O’sullivan; Uri Elkayam; Shabudin H. Rahimtoola; Laura Weber; Sheldon Gottlieb; Carol Brown; Mariell D. Jessup; Susan Ulrich; Jane Kronenthal; Denise Capaccio; Colin Grant; Edward Gillie; Pat Wood; Fetnat M. Fouad Tarazi; Kay Petey

doi:10.1001/jama.1988.03720040031022

Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure

Jay Cohn, Morton Hawkins, Herbert Levine, John Naughton, Elliot Rapaport, Sidney Goldstein, Bertram Pitt, Sidney Goldstein, Robert Cody, Prakash Deedwania, Leonard Dennick, Joseph Franciosa, Mark Mcgovern, Joseph Meyer, Bertram Pitt, Joseph Franciosa, Sidney Goldstein, Robert Cody, Prakash Deedwania, Alan GradmanBarry Massie, Milton Packer, James Doherty, Jacquelyn Gammill, William Cooper, Stanford Engel, Rita Fand, Barbara Hallows, Linda Kerwin, Debra A. Soltesz, John O. Parker, Karen Lahey, Prakash C. Deedwania, Enrique Carbajal, Pat Watson, Robert Dibianco, James A. Ronan, Dennis J. Donohue, Keith M. Lindgren, Louis J. Larca, Judy Freitag, Donna Lindemuth, Jeffrey B. Lakier, Howard S. Rosman, Mary Beth Wlodkowski, Robert J. Cody, Spencer H. Kubo, Mary Clark, Katie Pondolfino, Joseph A. Franciosa, Mary Wilen, Drexel Jordan, Sunil K. Das, John M. Nicklas, Mary Kay Foley, Michael B. Higginbotham, Frederick R. Cobb, Jean Wilson, David M. Berkson, Dragic Obradovic, Patricia Hershinow, N. Gary Nicholls, Hamid Ikram, Ian Crozier, Carl J. Pepine, John Culp, Marion Limacher, Kathy Mulvehill Verbust, D. John Farnham, Dorothy Adams, Norene Streicher, Carol Shanley, Mark A. Greenberg, Janet Strain, Mary Hewitt, Barbara Levine, D. Norman Sharpe, Robin Briant, Rene Coxon, Barry M. Massie, James W. Cornyn, Nina Topic, Harold Willens, Denise Antonishen, Dorothy Reinstein, Harry Colfer, Karen E. Graham, Gerald M. Perlow, Harvey S. Zarren, Barbara Bent, Marjorie Zicherman, Alan Gradman, Barry Zaret, Deborah Lawrason, Pat Tellier, Kathy O’keefe, Syed Mohiuddin, Lois Stengel, James D. Madison, Nancy Carruthers, Milton Packer, Fernando Elijovich, Mary O’sullivan, Uri Elkayam, Shabudin H. Rahimtoola, Laura Weber, Sheldon Gottlieb, Carol Brown, Mariell D. Jessup, Susan Ulrich, Jane Kronenthal, Denise Capaccio, Colin Grant, Edward Gillie, Pat Wood, Fetnat M. Fouad Tarazi, Kay Petey

Medicine - Cardiology Division

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Abstract

This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41% vs 22%), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4% increase) compared with captopril therapy (1.8% increase) and placebo (0.9% increase). The number of ventricular premature beats decreased 45% in the captopril group and increased 4% in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased requirements for diuretic therapy, and hospitalizations were significantly more frequent in patients receiving placebo compared with those receiving either active drug. Transitory hypotension occurred more frequently with administration of captopril. Captopril treatment is significantly more effective than placebo and is an alternative to digoxin therapy in patients with mild to moderate heart failure who are receiving diuretic maintenance therapy.

Original language	English (US)
Pages (from-to)	539-544
Number of pages	6
Journal	JAMA: The Journal of the American Medical Association
Volume	259
Issue number	4
DOIs	https://doi.org/10.1001/jama.1988.03720040031022
State	Published - Jan 22 1988

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Cohn, J., Hawkins, M., Levine, H., Naughton, J., Rapaport, E., Goldstein, S., Pitt, B., Goldstein, S., Cody, R., Deedwania, P., Dennick, L., Franciosa, J., Mcgovern, M., Meyer, J., Pitt, B., Franciosa, J., Goldstein, S., Cody, R., Deedwania, P., ... Petey, K. (1988). Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure. JAMA: The Journal of the American Medical Association, 259(4), 539-544. https://doi.org/10.1001/jama.1988.03720040031022

Cohn, J, Hawkins, M, Levine, H, Naughton, J, Rapaport, E, Goldstein, S, Pitt, B, Goldstein, S, Cody, R, Deedwania, P, Dennick, L, Franciosa, J, Mcgovern, M, Meyer, J, Pitt, B, Franciosa, J, Goldstein, S, Cody, R, Deedwania, P, Gradman, A, Massie, B, Packer, M, Doherty, J, Gammill, J, Cooper, W, Engel, S, Fand, R, Hallows, B, Kerwin, L, Soltesz, DA, Parker, JO, Lahey, K, Deedwania, PC, Carbajal, E, Watson, P, Dibianco, R, Ronan, JA, Donohue, DJ, Lindgren, KM, Larca, LJ, Freitag, J, Lindemuth, D, Lakier, JB, Rosman, HS, Wlodkowski, MB, Cody, RJ, Kubo, SH, Clark, M, Pondolfino, K, Franciosa, JA, Wilen, M, Jordan, D, Das, SK, Nicklas, JM, Foley, MK, Higginbotham, MB, Cobb, FR, Wilson, J, Berkson, DM, Obradovic, D, Hershinow, P, Nicholls, NG, Ikram, H, Crozier, I, Pepine, CJ, Culp, J, Limacher, M, Mulvehill Verbust, K, Farnham, DJ, Adams, D, Streicher, N, Shanley, C, Greenberg, MA, Strain, J, Hewitt, M, Levine, B, Sharpe, DN, Briant, R, Coxon, R, Massie, BM, Cornyn, JW, Topic, N, Willens, H, Antonishen, D, Reinstein, D, Colfer, H, Graham, KE, Perlow, GM, Zarren, HS, Bent, B, Zicherman, M, Gradman, A, Zaret, B, Lawrason, D, Tellier, P, O’keefe, K, Mohiuddin, S, Stengel, L, Madison, JD, Carruthers, N, Packer, M, Elijovich, F, O’sullivan, M, Elkayam, U, Rahimtoola, SH, Weber, L, Gottlieb, S, Brown, C, Jessup, MD, Ulrich, S, Kronenthal, J, Capaccio, D, Grant, C, Gillie, E, Wood, P, Fouad Tarazi, FM & Petey, K 1988, 'Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure', JAMA: The Journal of the American Medical Association, vol. 259, no. 4, pp. 539-544. https://doi.org/10.1001/jama.1988.03720040031022

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abstract = "This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41% vs 22%), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4% increase) compared with captopril therapy (1.8% increase) and placebo (0.9% increase). The number of ventricular premature beats decreased 45% in the captopril group and increased 4% in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased requirements for diuretic therapy, and hospitalizations were significantly more frequent in patients receiving placebo compared with those receiving either active drug. Transitory hypotension occurred more frequently with administration of captopril. Captopril treatment is significantly more effective than placebo and is an alternative to digoxin therapy in patients with mild to moderate heart failure who are receiving diuretic maintenance therapy.",

author = "Jay Cohn and Morton Hawkins and Herbert Levine and John Naughton and Elliot Rapaport and Sidney Goldstein and Bertram Pitt and Sidney Goldstein and Robert Cody and Prakash Deedwania and Leonard Dennick and Joseph Franciosa and Mark Mcgovern and Joseph Meyer and Bertram Pitt and Joseph Franciosa and Sidney Goldstein and Robert Cody and Prakash Deedwania and Alan Gradman and Barry Massie and Milton Packer and James Doherty and Jacquelyn Gammill and William Cooper and Stanford Engel and Rita Fand and Barbara Hallows and Linda Kerwin and Soltesz, {Debra A.} and Parker, {John O.} and Karen Lahey and Deedwania, {Prakash C.} and Enrique Carbajal and Pat Watson and Robert Dibianco and Ronan, {James A.} and Donohue, {Dennis J.} and Lindgren, {Keith M.} and Larca, {Louis J.} and Judy Freitag and Donna Lindemuth and Lakier, {Jeffrey B.} and Rosman, {Howard S.} and Wlodkowski, {Mary Beth} and Cody, {Robert J.} and Kubo, {Spencer H.} and Mary Clark and Katie Pondolfino and Franciosa, {Joseph A.} and Mary Wilen and Drexel Jordan and Das, {Sunil K.} and Nicklas, {John M.} and Foley, {Mary Kay} and Higginbotham, {Michael B.} and Cobb, {Frederick R.} and Jean Wilson and Berkson, {David M.} and Dragic Obradovic and Patricia Hershinow and Nicholls, {N. Gary} and Hamid Ikram and Ian Crozier and Pepine, {Carl J.} and John Culp and Marion Limacher and {Mulvehill Verbust}, Kathy and Farnham, {D. John} and Dorothy Adams and Norene Streicher and Carol Shanley and Greenberg, {Mark A.} and Janet Strain and Mary Hewitt and Barbara Levine and Sharpe, {D. Norman} and Robin Briant and Rene Coxon and Massie, {Barry M.} and Cornyn, {James W.} and Nina Topic and Harold Willens and Denise Antonishen and Dorothy Reinstein and Harry Colfer and Graham, {Karen E.} and Perlow, {Gerald M.} and Zarren, {Harvey S.} and Barbara Bent and Marjorie Zicherman and Alan Gradman and Barry Zaret and Deborah Lawrason and Pat Tellier and Kathy O{\textquoteright}keefe and Syed Mohiuddin and Lois Stengel and Madison, {James D.} and Nancy Carruthers and Milton Packer and Fernando Elijovich and Mary O{\textquoteright}sullivan and Uri Elkayam and Rahimtoola, {Shabudin H.} and Laura Weber and Sheldon Gottlieb and Carol Brown and Jessup, {Mariell D.} and Susan Ulrich and Jane Kronenthal and Denise Capaccio and Colin Grant and Edward Gillie and Pat Wood and {Fouad Tarazi}, {Fetnat M.} and Kay Petey",

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AU - Rapaport, Elliot

AU - Goldstein, Sidney

AU - Pitt, Bertram

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AU - Cody, Robert

AU - Deedwania, Prakash

AU - Dennick, Leonard

AU - Franciosa, Joseph

AU - Mcgovern, Mark

AU - Meyer, Joseph

AU - Pitt, Bertram

AU - Franciosa, Joseph

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AU - Cody, Robert

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AU - Cooper, William

AU - Engel, Stanford

AU - Fand, Rita

AU - Hallows, Barbara

AU - Kerwin, Linda

AU - Soltesz, Debra A.

AU - Parker, John O.

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AU - Deedwania, Prakash C.

AU - Carbajal, Enrique

AU - Watson, Pat

AU - Dibianco, Robert

AU - Ronan, James A.

AU - Donohue, Dennis J.

AU - Lindgren, Keith M.

AU - Larca, Louis J.

AU - Freitag, Judy

AU - Lindemuth, Donna

AU - Lakier, Jeffrey B.

AU - Rosman, Howard S.

AU - Wlodkowski, Mary Beth

AU - Cody, Robert J.

AU - Kubo, Spencer H.

AU - Clark, Mary

AU - Pondolfino, Katie

AU - Franciosa, Joseph A.

AU - Wilen, Mary

AU - Jordan, Drexel

AU - Das, Sunil K.

AU - Nicklas, John M.

AU - Foley, Mary Kay

AU - Higginbotham, Michael B.

AU - Cobb, Frederick R.

AU - Wilson, Jean

AU - Berkson, David M.

AU - Obradovic, Dragic

AU - Hershinow, Patricia

AU - Nicholls, N. Gary

AU - Ikram, Hamid

AU - Crozier, Ian

AU - Pepine, Carl J.

AU - Culp, John

AU - Limacher, Marion

AU - Mulvehill Verbust, Kathy

AU - Farnham, D. John

AU - Adams, Dorothy

AU - Streicher, Norene

AU - Shanley, Carol

AU - Greenberg, Mark A.

AU - Strain, Janet

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AU - Levine, Barbara

AU - Sharpe, D. Norman

AU - Briant, Robin

AU - Coxon, Rene

AU - Massie, Barry M.

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AU - Willens, Harold

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AU - Colfer, Harry

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AU - Perlow, Gerald M.

AU - Zarren, Harvey S.

AU - Bent, Barbara

AU - Zicherman, Marjorie

AU - Gradman, Alan

AU - Zaret, Barry

AU - Lawrason, Deborah

AU - Tellier, Pat

AU - O’keefe, Kathy

AU - Mohiuddin, Syed

AU - Stengel, Lois

AU - Madison, James D.

AU - Carruthers, Nancy

AU - Packer, Milton

AU - Elijovich, Fernando

AU - O’sullivan, Mary

AU - Elkayam, Uri

AU - Rahimtoola, Shabudin H.

AU - Weber, Laura

AU - Gottlieb, Sheldon

AU - Brown, Carol

AU - Jessup, Mariell D.

AU - Ulrich, Susan

AU - Kronenthal, Jane

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AU - Grant, Colin

AU - Gillie, Edward

AU - Wood, Pat

AU - Fouad Tarazi, Fetnat M.

AU - Petey, Kay

PY - 1988/1/22

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N2 - This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41% vs 22%), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4% increase) compared with captopril therapy (1.8% increase) and placebo (0.9% increase). The number of ventricular premature beats decreased 45% in the captopril group and increased 4% in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased requirements for diuretic therapy, and hospitalizations were significantly more frequent in patients receiving placebo compared with those receiving either active drug. Transitory hypotension occurred more frequently with administration of captopril. Captopril treatment is significantly more effective than placebo and is an alternative to digoxin therapy in patients with mild to moderate heart failure who are receiving diuretic maintenance therapy.

AB - This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41% vs 22%), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4% increase) compared with captopril therapy (1.8% increase) and placebo (0.9% increase). The number of ventricular premature beats decreased 45% in the captopril group and increased 4% in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased requirements for diuretic therapy, and hospitalizations were significantly more frequent in patients receiving placebo compared with those receiving either active drug. Transitory hypotension occurred more frequently with administration of captopril. Captopril treatment is significantly more effective than placebo and is an alternative to digoxin therapy in patients with mild to moderate heart failure who are receiving diuretic maintenance therapy.

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JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

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ER -

Comparative Effects of Therapy With Captopril and Digoxin in Patients With Mild to Moderate Heart Failure

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