TY - JOUR
T1 - Comparative evaluation of immunization with live attenuated and enhanced-potency inactivated trivalent poliovirus vaccines in childhood
T2 - Systemic and local immune responses
AU - Faden, Howard
AU - Modlin, John F.
AU - Thoms, Mary Lou
AU - McBean, A. Marshall
AU - Ferdon, Mary Beth
AU - Ogra, Pearay L.
PY - 1990/12
Y1 - 1990/12
N2 - Serum neutralizing, nasopharyngeal neutralizing, and 1gA antibodies were determined in 123 infants immunized with one of four schedules containing live oral vaccine (OPV), inactivated vaccine (IPV), or combinations of the two trivalent poliovirus vaccines: OPV-OPV-OPV, IPV-IPV, IPV-OPV-OPV, or IPV-IPV-OPV. Nearly 100% of individuals formed serum neutralizing antibodies. The highest geometric mean titer (GMT) of antibody to polioviruses 1, 2, and 3 occurred in groups IPV-IPV-OPV, IPV-OPV-OPV, and IPV-IPV-IPV, respectively. Local neutralizing and 1gA antibody responses were detected in 41%–88% and 75%–100%, respectively. Peak GMT of nasopharyngeal antibodies differed minimally between immunization groups. The data suggest that incorporation of at least one dose of IPV at the start of the immunization schedule tends to increase systemic as well as local antibody production.
AB - Serum neutralizing, nasopharyngeal neutralizing, and 1gA antibodies were determined in 123 infants immunized with one of four schedules containing live oral vaccine (OPV), inactivated vaccine (IPV), or combinations of the two trivalent poliovirus vaccines: OPV-OPV-OPV, IPV-IPV, IPV-OPV-OPV, or IPV-IPV-OPV. Nearly 100% of individuals formed serum neutralizing antibodies. The highest geometric mean titer (GMT) of antibody to polioviruses 1, 2, and 3 occurred in groups IPV-IPV-OPV, IPV-OPV-OPV, and IPV-IPV-IPV, respectively. Local neutralizing and 1gA antibody responses were detected in 41%–88% and 75%–100%, respectively. Peak GMT of nasopharyngeal antibodies differed minimally between immunization groups. The data suggest that incorporation of at least one dose of IPV at the start of the immunization schedule tends to increase systemic as well as local antibody production.
UR - http://www.scopus.com/inward/record.url?scp=0025203093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025203093&partnerID=8YFLogxK
U2 - 10.1093/infdis/162.6.1291
DO - 10.1093/infdis/162.6.1291
M3 - Article
C2 - 2172403
AN - SCOPUS:0025203093
VL - 162
SP - 1291
EP - 1297
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 6
ER -