Comparing CST Lesion Metrics as Biomarkers for Recovery of Motor and Proprioceptive Impairments After Stroke

Sonja E. Findlater, Rachel L. Hawe, Erin L. Mazerolle, Abdulaziz S. Al Sultan, Jessica M. Cassidy, Stephen H. Scott, G. Bruce Pike, Sean P. Dukelow

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background. Corticospinal tract (CST) damage is considered a biomarker for stroke recovery. Several methods have been used to define CST damage and examine its relationship to motor performance, but which method is most useful remains unclear. Proprioceptive impairment also affects stroke recovery and may be related to CST damage. Methods. Robotic assessment quantified upper-limb motor and proprioceptive performance at 2 weeks and 6 months poststroke (n = 149). Three previously-established CST lesion metrics were calculated using clinical neuroimaging. Diffusion magnetic resonance imaging quantified CST microstructure in a subset of participants (n = 21). Statistical region of interest (sROI) analysis identified lesion locations associated with motor and proprioceptive deficits. Results. CST lesion metrics were moderately correlated with motor scores at 2 weeks and 6 months poststroke. CST fractional anisotropy (FA) was correlated with motor scores at 1 month poststroke, but not at 6 months. The FA ratio of the posterior limb of the internal capsule was not correlated with motor performance. CST lesion metrics were moderately correlated with proprioceptive scores at 2 weeks and 6 months poststroke. sROI analysis confirmed that CST damage was associated with motor and proprioceptive deficits and additionally found that putamen, internal capsule, and corticopontocerebellar tract lesions were associated with poor motor performance. Conclusions. Across all methods used to quantify CST damage, correlations with motor or proprioceptive performance were moderate at best. Future research is needed to identify complementary or alternative biomarkers to address the complexity and heterogeneity of stroke recovery.

Original languageEnglish (US)
Pages (from-to)848-861
Number of pages14
JournalNeurorehabilitation and Neural Repair
Volume33
Issue number10
DOIs
StatePublished - Oct 1 2019
Externally publishedYes

Bibliographical note

Funding Information:
We acknowledge Janice Yajure and Mark Piitz for assistance in data collection and Dr Steven C. Cramer for his assistance with the CST percentage injury calculation. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The present work was supported by a Canadian Institutes of Health Research Grant (MOP 106662), and a Heart and Stroke Foundation of Canada Grant-in-Aid (G-13-003029). SEF was supported by an Alberta Innovates Health Solutions Clinical Fellowship.

Publisher Copyright:
© The Author(s) 2019.

Keywords

  • corticospinal tracts
  • motor skills
  • proprioception
  • robotic assessment
  • sensory motor performance
  • stroke rehabilitation

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