TY - JOUR
T1 - Comparing measures of medication taking in a pharmacotherapy trial for cocaine dependence
AU - Mooney, Marc
AU - Sayre, Shelly
AU - Green, Charles
AU - Rhoades, Howard
AU - Schmitz, Joy
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - The purpose of this study was to compare compliance estimates based on 3 methods of measuring medication taking: self-report, an electronic medication event measurement system (MEMS), and a biochemical tracer (riboflavin). During the first 4 weeks of a placebo-controlled, double-blind trial, cocaine-dependent participants (N = 55) took their assigned study medications and provided data to assess daily pill-taking behavior. MEMS-based estimates of medication compliance were substantially lower than riboflavin or self-report (28%, 78%, and 87%, respectively). Using MEMS as a reference or "gold standard," self-report, riboflavin, and their combination demonstrated poor ability to detect non-compliance (AUCs < 0.60). Medication compliance rates vary depending on measurement method, with subjective reports more likely to overestimate actual pill-taking behavior.
AB - The purpose of this study was to compare compliance estimates based on 3 methods of measuring medication taking: self-report, an electronic medication event measurement system (MEMS), and a biochemical tracer (riboflavin). During the first 4 weeks of a placebo-controlled, double-blind trial, cocaine-dependent participants (N = 55) took their assigned study medications and provided data to assess daily pill-taking behavior. MEMS-based estimates of medication compliance were substantially lower than riboflavin or self-report (28%, 78%, and 87%, respectively). Using MEMS as a reference or "gold standard," self-report, riboflavin, and their combination demonstrated poor ability to detect non-compliance (AUCs < 0.60). Medication compliance rates vary depending on measurement method, with subjective reports more likely to overestimate actual pill-taking behavior.
KW - MEMS
KW - Medication compliance
KW - ROC curve
KW - Riboflavin
KW - Self report
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U2 - 10.1097/01.adt.0000132509.65041.bf
DO - 10.1097/01.adt.0000132509.65041.bf
M3 - Article
AN - SCOPUS:10644225435
SN - 1531-5754
VL - 3
SP - 165
EP - 173
JO - Addictive Disorders and their Treatment
JF - Addictive Disorders and their Treatment
IS - 4
ER -