Abstract
A total of 105 ambulatory patients presenting with symptoms suggestive of cystitis was allocated randomly to a 4 or a 10-day course of doxycycline therapy. Of these patients 62 (59 per cent) had documented infections and 41 (66 per cent) were infected with doxycycline-sensitive organisms: 24 were randomized to a 4-day course and 17 to a 10-day course of antibiotic. The groups were similar with respect to age, history of urinary tract infection, bacteriology and site of infection. Of the 4-day treatment group 90 per cent were free of infection 42 days after completion of therapy, compared to 92 per cent in the 10-day treatment group. Thus, patients with symptoms of cystitis may be treated with a short course of an appropriate antibiotic, provided careful followup is made 4 to 6 weeks after cessation of therapy. The site of urinary infection of doxycycline-resistant and sensitive organisms was determined by the antibody-coated bacteria techniques in 56 episodes: 13 (23 per cent) originated in kidneys, 34 (61 per cent) originated in bladder foci and the results in 9 (16 per cent) were indeterminate. Results of the antibody-coated bacteria technique did not predict therapeutic outcome.
Original language | Undefined/Unknown |
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Pages (from-to) | 643-645 |
Number of pages | 3 |
Journal | Journal of Urology |
Volume | 124 |
Issue number | 5 |
State | Published - 1980 |
Keywords
- Adolescent
- Adult
- Aged
- Cystitis/dt [Drug Therapy]
- Cystitis/mi [Microbiology]
- Cystitis/ur [Urine]
- Doxycycline/ad [Administration & Dosage]
- Drug Administration Schedule
- Female
- Fluorescent Antibody Technique
- Humans
- Middle Aged
- Recurrence
- Time Factors
- Urinary Tract Infections/dt [Drug Therapy]
- Urinary Tract Infections/mi [Microbiology]
- Urinary Tract Infections/ur [Urine]