Abstract
The complete amino acid sequence for papain-solubilized HLA-B7 heavy chain is compared with the partial sequences of HLA-A2 and H-2K(b) heavy chains. Although these molecules are highly conserved (i.e., 80% homology in comparing HLA-B7 with HLA-A2; 72% and 74% homology in comparing H-2K(b) with HLA-A2 and HLA-B7, respectively), two stretches of greater variability are observed. These clusters of variability are discussed in terms of their possible involvement in the alloantigenic determinant(s) characteristic of these highly polymorphic membrane antigens.
Original language | English (US) |
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Pages (from-to) | 4395-4399 |
Number of pages | 5 |
Journal | Unknown Journal |
Volume | 76 |
Issue number | 9 |
DOIs | |
State | Published - 1979 |