Comparison of epidurally administered sufentanil, morphine, and sufentanil-morphine combination for postoperative analgesia

R. S. Sinatra, F. B. Sevarino, J. H. Chung, G. Graf, D. Paige, V. Takla, D. G. Silverman

Research output: Contribution to journalArticlepeer-review

Abstract

Postoperative analgesia provided by epidurally administered sufentanil and/or morphine was evaluated in 45 patients recovering from major gynecologic surgery. At the first complaint of pain in the Postanesthesia Care Unit, patients received a single epidural bolus of 30 μg sufentanil (group A), 5 mg morphine (group B), or 30 μg sufentanil plus 3 mg morphine (group C) in a randomized blinded fashion. Analgesic efficacy was assessed throughout the 24-h study period with 10-cm visual analog scales. The need for additional postoperative analgesia (patient-controlled analgesia, 1 mg of morphine every 6 min as necessary) and the incidence of adverse effects were also assessed. Patients receiving sufentanil (groups A and C) had significantly faster onset of analgesia than did patients given morphine alone (group B, P < 0.05). Group B subjects experienced the longest duration of analgesia (B vs A and C, P < 0.05) and required significantly less patient-controlled analgesia (morphine) than patients in group A (P < 0.05). No patient developed clinically significant respiratory depression or excessive sedation, and there were no intergroup differences in incidence of pruritus or nausea (P value not significant). The data indicate that a mixture of sufentanil and morphine provides either a more rapid onset of epidural analgesia or reduced patient-controlled analgesia narcotic requirement than respective doses of each agent administered alone.

Original languageEnglish (US)
Pages (from-to)522-527
Number of pages6
JournalAnesthesia and analgesia
Volume72
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • analgesics, morphine, sufentanil
  • anesthetic techniques, epidural - opioids
  • pain, postoperative

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