Comparison of human polymorphonuclear neutrophil elastase, polymorphonuclear neutrophil cathepsin-G, and α2-macroglobulin levels in healthy and inflamed dental pulps

Cindy R. Rauschenberger, Scott B. McClanahan, Ernest D. Pederson, Donald W. Turner, Edward J. Kaminski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Polymorphonuclear neutrophils (PMNs) are found in dental pulp secondary to carious exposures, periodontal disease, or trauma. Lysosomal degranulation of these cells liberates cellular proteases, including elastase (PMN-E) and cathepsin-G (PMN-CG), which produce connective tissue degradation. However, nonspecific pulpal tissue destruction can be modified by a naturally occurring serum protease inhibitor α2-macroglobulin (A2-M). This study relates the concentrations of human PMN-E, PMN-CG, and A2-M in healthy and inflamed pulpal samples. Evaluation of 21 specimens yielded statistically significant differences between healthy and moderate to severely inflamed pulps for all groups (p < 0.05). No significant correlation was detected among human PMN-E, PMN-CG, and A2-M in the healthy tissues (p > 0.05). However, in the moderate to severely inflamed pulps, there was a significant correlation between PMN-CG and A2-M (p < 0.05).

Original languageEnglish (US)
Pages (from-to)546-549
Number of pages4
JournalJournal of Endodontics
Volume20
Issue number11
DOIs
StatePublished - Nov 1994

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