Abstract
Bacterial resistance presents a difficult issue for fluoroquinolone treatment of bacterial infections. In previous work, we reported that 8-methoxy-quinazoline-2,4-diones are active against quinolone-resistant mutants of Escherichia coli. Here, we demonstrate the activity of a representative 8-methoxy-quinazoline-2,4-dione against quinolone-resistant gyrases. Furthermore, 8-methoxy-quinazoline-2,4-dione and other diones are shown to inhibit Staphylococcus aureus gyrase and topoisomerase IV with similar degrees of efficacy, suggesting that the diones might act as dual-targeting agents against S. aureus.
Original language | English (US) |
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Pages (from-to) | 3011-3014 |
Number of pages | 4 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 54 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2010 |