Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium

Brent W. Gunderson; Khalid H. Ibrahim; Charles A. Peloquin; Laurie B. Hovde; John C. Rotschafer

doi:10.1128/AAC.47.1.398-399.2003

Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium

Brent W. Gunderson, Khalid H. Ibrahim, Charles A. Peloquin, Laurie B. Hovde, John C. Rotschafer

Experimental and Clinical Pharmacology

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Abstract

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log₁₀ killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.

Original language	English (US)
Pages (from-to)	398-399
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	47
Issue number	1
DOIs	https://doi.org/10.1128/AAC.47.1.398-399.2003
State	Published - Jan 1 2003

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Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. / Gunderson, Brent W.; Ibrahim, Khalid H.; Peloquin, Charles A. et al.
In: Antimicrobial agents and chemotherapy, Vol. 47, No. 1, 01.01.2003, p. 398-399.

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Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium

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