Comparison of measurements by multiple methods or instruments

Douglas M. Hawkins, Abha Sharma

Research output: Contribution to journalArticlepeer-review


Much work has been done on comparison of one device with another, but the problem of comparing three or more devices is less well known. Most existing work has concentrated on the possibilities of a constant relative bias between the devices, or of different linear relationships with the underlying true value. These two possibilities are placed within a hierarchy of models extending them to settings with multiplicative interaction terms. These additional terms can capture departures such as outliers, variance changing with the analyte concentration, and different measurement variances between the devices.

Original languageEnglish (US)
Pages (from-to)965-984
Number of pages20
JournalJournal of Biopharmaceutical Statistics
Issue number5
StatePublished - Sep 1 2010


  • Analysis of variance
  • Bland-Altman plot
  • Methods comparison
  • Multiplicative interactions

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