Comparison of the fibrinolytic response to desmopressin acetate (DDAVP) infusion versus venous occlusion in patients with coronary artery disease

D. Duprez, G. Baele, M. De Buyzere, P. Vandenbroecke, D. L. Clement

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5 Scopus citations

Abstract

A 20-min venous occlusion and a desmopressin acetate (DDAVP, 0.4 μg.Kg-1, 15 min) infusion test have been compared to evaluate fibrinolytic capacity in proven coronary artery disease. Basal values of plasma tissue plasminogen activator (t-PA)activity and antigen and of t-PA inhibitor (PAI) were normally distributed in this patient group. However, after both stimuli, highly signficant (P < 0.005) increases of t-PA antigen and activity have been observed. Renormalization of t-PA levels after DDAVP infusion occurred more rapidly for antigen (120 min) than for activity concentrations (> 240 min). A DDAVP infusion test seems more appropriate for evaluation of the fibrinolytic capacity as the induced decrease in PAI level was significant (P < 0.005) and lasted for at least 240 min, while it was not significant for the venous occlusion test.

Original languageEnglish (US)
Pages (from-to)800-802
Number of pages3
JournalEuropean Heart Journal
Volume12
Issue number7
StatePublished - Dec 1 1991

Keywords

  • Coronary artery disease
  • Desmopressin
  • Fibrinolysis
  • Venous occlusion

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