Complementing genomics and transcriptomics: Phosphoproteomics illuminates systems biology in prostate cancer

Victor M. Tan, Larry C. Cheng, Justin M. Drake

Research output: Contribution to journalComment/debatepeer-review

3 Scopus citations

Abstract

Integration of phosphoproteomics with traditional genomics and transcriptomics provides a more comprehensive overview of the signaling networks in advanced prostate cancer for immediate preclinical and future clinical use. Our recent publication introduces computational approaches for integrating the phosphoproteome, specifically with the intent of identifying important kinase signaling networks in advanced-stage prostate cancer.

Original languageEnglish (US)
Article numbere1246075
JournalMolecular and Cellular Oncology
Volume3
Issue number6
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Bibliographical note

Funding Information:
LCC is supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number T32 GM008339. JMD is supported by the Department of Defense Prostate Cancer Research Program W81XWH-15-1-0236, Prostate Cancer Foundation Young Investigator Award, and by a grant from the New Jersey Health Foundation.

Publisher Copyright:
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Victor M. Tan, Larry C. Cheng, and Justin M. Drake.

Keywords

  • Castration-resistant prostate cancer
  • kinases
  • phosphoproteomics
  • precision medicine
  • systems biology

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