TY - JOUR
T1 - Complete genome sequence and analysis of Wolinella succinogenes
AU - Baar, Claudia
AU - Eppinger, Mark
AU - Raddatz, Guenter
AU - Simon, Jörg
AU - Lanz, Christa
AU - Klimmek, Oliver
AU - Nandakumar, Ramkumar
AU - Gross, Roland
AU - Rosinus, Andrea
AU - Keller, Heike
AU - Jagtap, Pratik
AU - Linke, Burkhard
AU - Meyer, Folker
AU - Lederer, Hermann
AU - Schuster, Stephan C.
PY - 2003/9/30
Y1 - 2003/9/30
N2 - To understand the origin and emergence of pathogenic bacteria, knowledge of the genetic inventory from their nonpathogenic relatives is a prerequisite. Therefore, the 2.11-megabase genome sequence of Wolinella succinogenes, which is closely related to the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni, was determined. Despite being considered nonpathogenic to its bovine host, W. succinogenes holds an extensive repertoire of genes homologous to known bacterial virulence factors. Many of these genes have been acquired by lateral gene transfer, because part of the virulence plasmid pVir and an N-linked glycosylation gene cluster were found to be syntenic between C. jejuni and genomic islands of W. succinogenes. In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. Because the analysis of the W. succinogenes genome also revealed genes related to soil- and plant-associated bacteria such as the nif genes, W. succinogenes may represent a member of the epsilon proteobacteria with a life cycle outside its host.
AB - To understand the origin and emergence of pathogenic bacteria, knowledge of the genetic inventory from their nonpathogenic relatives is a prerequisite. Therefore, the 2.11-megabase genome sequence of Wolinella succinogenes, which is closely related to the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni, was determined. Despite being considered nonpathogenic to its bovine host, W. succinogenes holds an extensive repertoire of genes homologous to known bacterial virulence factors. Many of these genes have been acquired by lateral gene transfer, because part of the virulence plasmid pVir and an N-linked glycosylation gene cluster were found to be syntenic between C. jejuni and genomic islands of W. succinogenes. In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. Because the analysis of the W. succinogenes genome also revealed genes related to soil- and plant-associated bacteria such as the nif genes, W. succinogenes may represent a member of the epsilon proteobacteria with a life cycle outside its host.
KW - Bacterial pathogenicity
KW - Campylobacter
KW - Epsilon proteobacteria
KW - Helicobacter
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U2 - 10.1073/pnas.1932838100
DO - 10.1073/pnas.1932838100
M3 - Article
C2 - 14500908
AN - SCOPUS:0141705354
SN - 0027-8424
VL - 100
SP - 11690
EP - 11695
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 20
ER -