Complete genome sequence of cell culture-attenuated guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome

Dongmei Yang; Zohaib Alam; Xiaohong Cui; Michael Chen; Carly J. Sherrod; Michael A. McVoy; Mark R. Schleiss; Dirk P. Dittmer

doi:10.1128/genomeA.00928-14

Complete genome sequence of cell culture-attenuated guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome

Dongmei Yang, Zohaib Alam, Xiaohong Cui, Michael Chen, Carly J. Sherrod, Michael A. McVoy, Mark R. Schleiss, Dirk P. Dittmer

Pediatrics - Infectious Disease

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6 Scopus citations

Abstract

The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.

Original language	English (US)
Article number	e00928-14
Journal	Genome Announcements
Volume	2
Issue number	5
DOIs	https://doi.org/10.1128/genomeA.00928-14
State	Published - 2014

Bibliographical note

Funding Information:
This work was supported by Public Health Service grant 2RO1HD044864 (to M.R.S.) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, grant 5PO1CA019014 (to D.P.D.) from the National Cancer Institute, and grants 1U19AI107810 (to D.P.D.) and 1RO3AI083919 (to M.A.M.) from the National Institute of Allergy and Infectious Diseases.

Publisher Copyright:
© 2014 Yang et al.

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abstract = "The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.",

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AU - Alam, Zohaib

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AU - Chen, Michael

AU - Sherrod, Carly J.

AU - McVoy, Michael A.

AU - Schleiss, Mark R.

AU - Dittmer, Dirk P.

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Complete genome sequence of cell culture-attenuated guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome

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