Complete heart block in association with graft-versus-host disease

A. L. Gilman; N. W. Kooy; D. L. Atkins; Z. Ballas; S. Rumelhart; M. Holida; N. Lee; F. Goldman

doi:10.1038/sj.bmt.1701038

Complete heart block in association with graft-versus-host disease

A. L. Gilman, N. W. Kooy, D. L. Atkins, Z. Ballas, S. Rumelhart, M. Holida, N. Lee, F. Goldman

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21 Scopus citations

Abstract

An infant who received haploidentical BM for severe combined immunodeficiency (SCID) developed acute, reversible complete heart block in association with an exacerbation of GVHD. Respiratory distress and myocardial dysfunction were also seen with this and previous GVHD exacerbations. The patient had not received chemotherapy or radiation prior to BMT. The complete heart block resolved after 1 week of intensive immunosuppression. The association of complete heart block with GVHD is important because the heart block is potentially reversible with prompt, aggressive control of the GVHD.

Original language	English (US)
Pages (from-to)	85-88
Number of pages	4
Journal	Bone marrow transplantation
Volume	21
Issue number	1
DOIs	https://doi.org/10.1038/sj.bmt.1701038
State	Published - Jan 1 1998
Externally published	Yes

Keywords

Arrhythmia
Bone marrow transplantation
Cardiac
Graft-versus-host disease
Heart block

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AU - Gilman, A. L.

AU - Kooy, N. W.

AU - Atkins, D. L.

AU - Ballas, Z.

AU - Rumelhart, S.

AU - Holida, M.

AU - Lee, N.

AU - Goldman, F.

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AB - An infant who received haploidentical BM for severe combined immunodeficiency (SCID) developed acute, reversible complete heart block in association with an exacerbation of GVHD. Respiratory distress and myocardial dysfunction were also seen with this and previous GVHD exacerbations. The patient had not received chemotherapy or radiation prior to BMT. The complete heart block resolved after 1 week of intensive immunosuppression. The association of complete heart block with GVHD is important because the heart block is potentially reversible with prompt, aggressive control of the GVHD.

KW - Arrhythmia

KW - Bone marrow transplantation

KW - Cardiac

KW - Graft-versus-host disease

KW - Heart block

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Complete heart block in association with graft-versus-host disease

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