Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex

So Iwata; Joong W. Lee; Kengo Okada; John Kyongwon Lee; Momi Iwata; Bjarne Rasmussen; Thomas A. Link; S. Ramaswamy; Bing K. Jap

doi:10.1126/science.281.5373.64

Complete structure of the 11-subunit bovine mitochondrial cytochrome bc₁ complex

So Iwata, Joong W. Lee, Kengo Okada, John Kyongwon Lee, Momi Iwata, Bjarne Rasmussen, Thomas A. Link, S. Ramaswamy, Bing K. Jap

Research output: Contribution to journal › Article › peer-review

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Abstract

Mitochondrial cytochrome bc₁ complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc₁ complex from bovine heart reveal full views of this bifunctional enzyme. The 'Rieske' iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the 'Rieske' protein (subunit 9) is lodged between the two 'core' subunits at the matrix side of the complex. These 'core' subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.

Original language	English (US)
Pages (from-to)	64-71
Number of pages	8
Journal	Science
Volume	281
Issue number	5373
DOIs	https://doi.org/10.1126/science.281.5373.64
State	Published - Jul 3 1998
Externally published	Yes

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abstract = "Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The 'Rieske' iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the 'Rieske' protein (subunit 9) is lodged between the two 'core' subunits at the matrix side of the complex. These 'core' subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.",

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AU - Lee, Joong W.

AU - Okada, Kengo

AU - Lee, John Kyongwon

AU - Iwata, Momi

AU - Rasmussen, Bjarne

AU - Link, Thomas A.

AU - Ramaswamy, S.

AU - Jap, Bing K.

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Complete structure of the 11-subunit bovine mitochondrial cytochrome bc₁ complex

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