TY - JOUR
T1 - Comprehensive Mutation Scanning of LMNA in 268 Patients With Lone Atrial Fibrillation
AU - Brauch, Katharine M.
AU - Chen, Lin Y.
AU - Olson, Timothy M.
PY - 2009/5/15
Y1 - 2009/5/15
N2 - Atrial fibrillation (AF) is a heritable, genetically heterogeneous disorder. To identify gene defects that cause or confer susceptibility to AF, a cohort of 268 unrelated patients with idiopathic forms of familial and sporadic AF was recruited. LMNA, encoding the nuclear membrane proteins, lamin A/C, was selected as a candidate gene for lone AF based on its established association with a syndrome of dilated cardiomyopathy, conduction system disease, and AF. Comprehensive mutation scanning identified only 1 potentially pathogenic mutation. In conclusion, LMNA mutations rarely cause lone AF and routine genetic testing of LMNA in these patients does not appear warranted.
AB - Atrial fibrillation (AF) is a heritable, genetically heterogeneous disorder. To identify gene defects that cause or confer susceptibility to AF, a cohort of 268 unrelated patients with idiopathic forms of familial and sporadic AF was recruited. LMNA, encoding the nuclear membrane proteins, lamin A/C, was selected as a candidate gene for lone AF based on its established association with a syndrome of dilated cardiomyopathy, conduction system disease, and AF. Comprehensive mutation scanning identified only 1 potentially pathogenic mutation. In conclusion, LMNA mutations rarely cause lone AF and routine genetic testing of LMNA in these patients does not appear warranted.
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U2 - 10.1016/j.amjcard.2009.01.354
DO - 10.1016/j.amjcard.2009.01.354
M3 - Article
C2 - 19427440
AN - SCOPUS:65449138689
SN - 0002-9149
VL - 103
SP - 1426
EP - 1428
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 10
ER -