Computationally guided design of robust gene circuits

Najaf A. Shah, Casim A. Sarkar

Research output: Contribution to journalArticlepeer-review

Abstract

The inability to rationally design and construct circuits that robustly enable complex behaviors is perhaps the most fundamental challenge in synthetic biology. While systems modeling can aid this process and help reduce the space of design strategies, the unavailability and dynamic variability of kinetic parameters limits the utility of such models. Here, we present a general approach that employs an exhaustive enumeration of network architectures to suggest topologies that robustly enable a desired behavior.

Original languageEnglish (US)
Pages (from-to)167-178
Number of pages12
JournalMethods in Molecular Biology
Volume1244
DOIs
StatePublished - Jan 1 2015

Keywords

  • Network topology
  • Synthetic circuit design
  • Systems modeling
  • Topology search

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