Computer-Aided Design of Synthetic Biological Constructs with the Synthetic Biology Software Suite

Katherine Volzing; Konstantinos Biliouris; Patrick Smadbeck; Yiannis Kaznessis

doi:10.1016/B978-0-12-394430-6.00007-8

Computer-Aided Design of Synthetic Biological Constructs with the Synthetic Biology Software Suite

Katherine Volzing, Konstantinos Biliouris, Patrick Smadbeck, Yiannis Kaznessis

Chemical Engineering and Materials Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We discuss the importance of mathematical modeling in synthetic biology. We present the essential elements of the Synthetic Biology Software Suite (SynBioSS) and discuss the experimental construction and testing of two synthetic biological devices as guided by SynBioSS. In addition, we discuss the computer-aided design of logical-AND gates and of protein devices in bacteria. © 2013

Original language	English (US)
Title of host publication	Synthetic Biology
Publisher	Elsevier Inc.
Pages	123-139
Number of pages	17
ISBN (Print)	9780123944306
DOIs	https://doi.org/10.1016/B978-0-12-394430-6.00007-8
State	Published - 2013

Bibliographical note

Funding Information:
This work was supported by a grant from the National Institutes of Health (American Recovery and Reinvestment Act grant GM086865) and a grant from the National Science Foundation (CBET-0644792). Partial funding for this work was also provided through a grant from the Synthetic Ecology Program of the Biotechnology Institute and from the Presidential Initiative on Biocatalysis at the University of Minnesota.

Keywords

Computer-aided design
Multiscale models
Protein devices
Synthetic biological networks

Access

10.1016/B978-0-12-394430-6.00007-8

OpenUrl availability

Full text

Cite this

@inbook{c24627550eae48beacd6146d11a846a6,

title = "Computer-Aided Design of Synthetic Biological Constructs with the Synthetic Biology Software Suite",

abstract = "We discuss the importance of mathematical modeling in synthetic biology. We present the essential elements of the Synthetic Biology Software Suite (SynBioSS) and discuss the experimental construction and testing of two synthetic biological devices as guided by SynBioSS. In addition, we discuss the computer-aided design of logical-AND gates and of protein devices in bacteria. {\textcopyright} 2013",

keywords = "Computer-aided design, Multiscale models, Protein devices, Synthetic biological networks",

author = "Katherine Volzing and Konstantinos Biliouris and Patrick Smadbeck and Yiannis Kaznessis",

note = "Funding Information: This work was supported by a grant from the National Institutes of Health (American Recovery and Reinvestment Act grant GM086865) and a grant from the National Science Foundation (CBET-0644792). Partial funding for this work was also provided through a grant from the Synthetic Ecology Program of the Biotechnology Institute and from the Presidential Initiative on Biocatalysis at the University of Minnesota.",

year = "2013",

doi = "10.1016/B978-0-12-394430-6.00007-8",

language = "English (US)",

isbn = "9780123944306",

pages = "123--139",

booktitle = "Synthetic Biology",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Computer-Aided Design of Synthetic Biological Constructs with the Synthetic Biology Software Suite

AU - Volzing, Katherine

AU - Biliouris, Konstantinos

AU - Smadbeck, Patrick

AU - Kaznessis, Yiannis

N1 - Funding Information: This work was supported by a grant from the National Institutes of Health (American Recovery and Reinvestment Act grant GM086865) and a grant from the National Science Foundation (CBET-0644792). Partial funding for this work was also provided through a grant from the Synthetic Ecology Program of the Biotechnology Institute and from the Presidential Initiative on Biocatalysis at the University of Minnesota.

PY - 2013

Y1 - 2013

N2 - We discuss the importance of mathematical modeling in synthetic biology. We present the essential elements of the Synthetic Biology Software Suite (SynBioSS) and discuss the experimental construction and testing of two synthetic biological devices as guided by SynBioSS. In addition, we discuss the computer-aided design of logical-AND gates and of protein devices in bacteria. © 2013

AB - We discuss the importance of mathematical modeling in synthetic biology. We present the essential elements of the Synthetic Biology Software Suite (SynBioSS) and discuss the experimental construction and testing of two synthetic biological devices as guided by SynBioSS. In addition, we discuss the computer-aided design of logical-AND gates and of protein devices in bacteria. © 2013

KW - Computer-aided design

KW - Multiscale models

KW - Protein devices

KW - Synthetic biological networks

UR - http://www.scopus.com/inward/record.url?scp=84882607432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882607432&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-394430-6.00007-8

DO - 10.1016/B978-0-12-394430-6.00007-8

M3 - Chapter

AN - SCOPUS:84882607432

SN - 9780123944306

SP - 123

EP - 139

BT - Synthetic Biology

PB - Elsevier Inc.

ER -

Computer-Aided Design of Synthetic Biological Constructs with the Synthetic Biology Software Suite

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this