Abstract
A highly concerted strategy for the synthesis of symmetrical type-VI β-turn mimics was formulated. A proof of concept is presented in the synthesis of a spirobicyclic peptidomimetic of Pro-Pro-Pro-NH2, compound 6. The formation of an unusual adduct that was encountered in the process also is reported. This approach is potentially general for type-VI β-turn mimics where the i + 1 and i + 2 residues are identical.
Original language | English (US) |
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Pages (from-to) | 983-986 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - Mar 2 2006 |