Concerted synthesis of a spirobicyclic type-VI β-turn mimic of Pro-Pro-Pro-NH2

Ashish P. Vartak, Rodney L. Johnson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A highly concerted strategy for the synthesis of symmetrical type-VI β-turn mimics was formulated. A proof of concept is presented in the synthesis of a spirobicyclic peptidomimetic of Pro-Pro-Pro-NH2, compound 6. The formation of an unusual adduct that was encountered in the process also is reported. This approach is potentially general for type-VI β-turn mimics where the i + 1 and i + 2 residues are identical.

Original languageEnglish (US)
Pages (from-to)983-986
Number of pages4
JournalOrganic Letters
Volume8
Issue number5
DOIs
StatePublished - Mar 2 2006

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