Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis

Robert C. Rennert; Reid R. Hoshide; Jason W. Signorelli; Deirdre Amaro; Jayson A. Sack; Cameron W. Brennan; Clark C. Chen

doi:10.3171/2016.4.JNS153052

Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis

Robert C. Rennert, Reid R. Hoshide, Jason W. Signorelli, Deirdre Amaro, Jayson A. Sack, Cameron W. Brennan, Clark C. Chen

Neurosurgery

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4 Scopus citations

Abstract

The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.

Original language	English (US)
Pages (from-to)	1472-1478
Number of pages	7
Journal	Journal of neurosurgery
Volume	126
Issue number	5
DOIs	https://doi.org/10.3171/2016.4.JNS153052
State	Published - May 2017

Bibliographical note

Publisher Copyright:
© AANS, 2017.

Keywords

Chromothripsis
Glioblastoma
Metastasis
Oncology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis",

abstract = "The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.",

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AU - Hoshide, Reid R.

AU - Signorelli, Jason W.

AU - Amaro, Deirdre

AU - Sack, Jayson A.

AU - Brennan, Cameron W.

AU - Chen, Clark C.

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AB - The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.

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KW - Metastasis

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Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis

Abstract

Bibliographical note

Keywords

UN SDGs

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