CONCURRENT PHENCYCLIDINE AND SACCHARIN ACCESS: PRESENTATION OF AN ALTERNATIVE REINFORCER REDUCES DRUG INTAKE

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Six monkeys self‐administered orally delivered phencyclidine (“angel dust”) and saccharin under concurrent fixed‐ratio 16 schedules during daily three‐hour sessions. Liquid deliveries were contingent upon lip‐contact responses on solenoid‐operated drinking spouts. Three saccharin concentrations (0.003%, 0.03% and 0.3%, wt/vol) were tested in a nonsystematic order. For each saccharin concentration, the following series of phencyclidine concentrations (mg/ml) was presented: 0.25, 0.5, 1, 0.25 (retest), 0.125, 0.0625, 0.0312, 0.25 (retest) and 0 (water with stimuli signaling phencyclidine). As the saccharin concentration increased, the number of drug deliveries decreased, and the peaks of the concentration‐response functions were shifted to the right. The lowest saccharin concentration (0.003%, wt/vol) maintained responding in excess of phencyclidine levels in only one monkey. The two higher saccharin concentrations maintained behavior far in excess of phencyclidine, but saccharin deliveries decreased in some monkeys as phencyclidine concentration and intake (mg/kg) increased. The time course and patterns of phencyclidine‐reinforced responding were also altered when saccharin was concurrently available. The results are discussed in terms of strategies to reduce drug‐reinforced behavior, preference between different reinforcers, and measures of reinforcing efficacy. 1985 Society for the Experimental Analysis of Behavior

Original languageEnglish (US)
Pages (from-to)131-144
Number of pages14
JournalJournal of the experimental analysis of behavior
Volume43
Issue number1
DOIs
StatePublished - Jan 1985

Keywords

  • concurrent fixed‐ratio schedules
  • lip‐contact response
  • oral drug self‐administration
  • phencyclidine
  • reinforcing efficacy
  • rhesus monkeys
  • saccharin
  • suppression of drug‐reinforced behavior

Fingerprint Dive into the research topics of 'CONCURRENT PHENCYCLIDINE AND SACCHARIN ACCESS: PRESENTATION OF AN ALTERNATIVE REINFORCER REDUCES DRUG INTAKE'. Together they form a unique fingerprint.

Cite this