Confocal microscopy study of nerves and blood vessels in untreated and treated port wine stains: Preliminary observations

Mona M. Selim, Kristen M. Kelly, J. Stuart Nelson, Gwen Wendelschafer-Crabb, William R. Kennedy, Brian D. Zelickson

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE. Vascular ectasia in port wine stain birthmarks (PWS) might result from reduced innervation with loss of autonomic stimulation. We investigated this theory and evaluated nerve and blood vessel density, and mean blood vessel size in untreated and treated PWS skin. METHODS. Skin biopsy specimens were obtained from uninvolved skin, untreated PWS, PWS with a good response to laser treatment and PWS with a poor response to laser treatment. Confocal microscopy was performed to determine nerve and blood vessel density, and mean blood vessel size. RESULTS. Nerve density was significantly decreased in all PWS sites compared to uninvolved skin. Mean blood vessel diameter was larger in untreated compared to treated PWS. PWS with a good response to treatment had decreased nerve density but blood vessel density and mean diameter was relatively normal. PWS with a poor response to treatment had decreased nerve density but increased blood vessel density and mean blood vessel diameter compared to normal skin. CONCLUSION. Nerve density was decreased in all evaluated PWS sites and this may be a factor in lesion pathogenesis. PWS blood vessel size correlated with pulsed dye laser response and may prove to be a useful prognostic indicator of therapeutic outcome.

Original languageEnglish (US)
Pages (from-to)892-897
Number of pages6
JournalDermatologic Surgery
Volume30
Issue number6
DOIs
StatePublished - Jun 2004

Fingerprint Dive into the research topics of 'Confocal microscopy study of nerves and blood vessels in untreated and treated port wine stains: Preliminary observations'. Together they form a unique fingerprint.

Cite this