TY - JOUR
T1 - Constituents of Cynanchum auriculatum and their inhibitory effect on melanogenesis in B16 mouse melanoma cell lines
AU - Choi, Hyun Gyu
AU - Jiang, Yanfu
AU - Roh, Eunmiri
AU - Kim, Youngsoo
AU - Xu, Guang Hua
AU - Na, Min Kyun
AU - Lee, Seung Ho
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Fourteen compounds were isolated from the roots of Cynanchum auriculatum and their chemical structures were identified as β-sitosterol (1), acetovanillone (2), p-hydroxyacetophenone (3), 2,4-dihydroxyacetophenone (4), 2,5-dihydroxyacetophenone (5), cynandione A (6), methyleugenol (7), daucosterol (8), Succinic acid (9), cynauriculoside A (10), wilfoside C3N (11), wilfoside C1N (12), wilfoside K1N (13) and wilfoside C1G (14). Among them, compounds 2-5 were isolated from this plant for the first time. And 2, 5-dihydroxyacetophenone (5) showed the most potent inhibitory effect on melanogenesis in B-16 mouse melanoma cell lines with IC50 value of 20 μM.
AB - Fourteen compounds were isolated from the roots of Cynanchum auriculatum and their chemical structures were identified as β-sitosterol (1), acetovanillone (2), p-hydroxyacetophenone (3), 2,4-dihydroxyacetophenone (4), 2,5-dihydroxyacetophenone (5), cynandione A (6), methyleugenol (7), daucosterol (8), Succinic acid (9), cynauriculoside A (10), wilfoside C3N (11), wilfoside C1N (12), wilfoside K1N (13) and wilfoside C1G (14). Among them, compounds 2-5 were isolated from this plant for the first time. And 2, 5-dihydroxyacetophenone (5) showed the most potent inhibitory effect on melanogenesis in B-16 mouse melanoma cell lines with IC50 value of 20 μM.
KW - 2, 5-dihydroxyacetophenone
KW - B16 cell lines
KW - Cynanchum auriculatum
KW - Melanogenesis
UR - http://www.scopus.com/inward/record.url?scp=81855216171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81855216171&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:81855216171
SN - 0253-3073
VL - 41
SP - 238
EP - 244
JO - Korean Journal of Pharmacognosy
JF - Korean Journal of Pharmacognosy
IS - 4
ER -
