Constituents of Cynanchum auriculatum and their inhibitory effect on melanogenesis in B16 mouse melanoma cell lines

Hyun Gyu Choi, Yanfu Jiang, Eunmiri Roh, Youngsoo Kim, Guang Hua Xu, Min Kyun Na, Seung Ho Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Fourteen compounds were isolated from the roots of Cynanchum auriculatum and their chemical structures were identified as β-sitosterol (1), acetovanillone (2), p-hydroxyacetophenone (3), 2,4-dihydroxyacetophenone (4), 2,5-dihydroxyacetophenone (5), cynandione A (6), methyleugenol (7), daucosterol (8), Succinic acid (9), cynauriculoside A (10), wilfoside C3N (11), wilfoside C1N (12), wilfoside K1N (13) and wilfoside C1G (14). Among them, compounds 2-5 were isolated from this plant for the first time. And 2, 5-dihydroxyacetophenone (5) showed the most potent inhibitory effect on melanogenesis in B-16 mouse melanoma cell lines with IC50 value of 20 μM.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalKorean Journal of Pharmacognosy
Volume41
Issue number4
StatePublished - Dec 1 2010

Keywords

  • 2, 5-dihydroxyacetophenone
  • B16 cell lines
  • Cynanchum auriculatum
  • Melanogenesis

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