Consumption of a high b-glucan barley flour improves glucose control and fatty liver and increases muscle acylcarnitines in the Zucker diabetic fatty rat

David A. Brockman, Xiaoli Chen, Daniel D. Gallaher

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Purpose The soluble fiber b-glucan, a natural component of barley, has been shown to lower the postprandial glucose response and is thought to improve insulin resistance. Methods This study examined the effect of chronic consumption of the high b-glucan barley flour on glucose control, liver lipids and markers of muscle fatty acid oxidation in the Zucker diabetic fatty (ZDF) rat. Two groups of ZDF rats were fed diets containing either 6 % b-glucan in the form of barley flour or cellulose as a control for 6 weeks. A group of Zucker lean rats served as a negative control. Results The barley flour group had an increased small intestinal contents viscosity compared to the obese control group. After 6 weeks, the barley flour group had reduced glycated hemoglobin, lower relative kidney weights and a reduced area under the curve during a glucose tolerance test, indicating improved glucose control. Fasting plasma adiponectin levels increased in the barley flour group and were not different than the lean control group. ZDF rats on the barley flour diet had lower relative epididymal fat pad weights than the obese control and a greater food efficiency ratio. The barley flour group also had reduced liver weights and a decreased concentration of liver lipids. The barley flour group had significantly higher concentrations of muscle acylcarnitines, a metabolite generated during fatty acid oxidation. Conclusion These results show that chronic consumption of b-glucans can improve glucose control and decrease fatty liver in a model of diabetes with obesity.

Original languageEnglish (US)
Pages (from-to)1743-1753
Number of pages11
JournalEuropean Journal of Nutrition
Volume52
Issue number7
DOIs
StatePublished - Oct 2013

Bibliographical note

Funding Information:
Acknowledgments We thank Nghia Le for liver extraction and lipid and cholesterol analysis and Ana Carla Gilberto dos Santos for urinary TBARS analysis. Supported by the University of Minnesota College of Human Ecology Legacy Funds and the Minnesota Agriculture Experiment Station.

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • Acylcarnitines
  • B-glucan
  • Dietary fiber
  • Fatty liver
  • Insulin resistance
  • Viscosity

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