Context matters: Contribution of specific DNA adducts to the genotoxic properties of the tobacco-specific nitrosamine NNK

Medicine & Life Sciences

• Nitrosamines 100%
• DNA Adducts 91%
• Hydroxylation 84%
• Carcinogens 70%
• Tobacco 69%
• Targeted Gene Repair 45%
• DNA Damage 42%
• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol 42%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 38%
• International Agencies 33%
• Metabolic Activation 29%
• Alkylating Agents 28%
• Laboratory Animals 28%
• DNA 27%
• Lung 26%
• Carbon 24%
• Cytochrome P-450 Enzyme System 23%
• Poisons 18%
• Mutation 13%
• Enzymes 13%
• Neoplasms 7%

Chemical Compounds

• Nitrosamine 96%
• Genotoxic 87%
• Adduct 52%
• Carcinogenic 46%
• 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol 26%
• Metabolic Activation 18%
• Alkylating Agent 17%
• Cytochrome P450 15%
• Mutation 12%
• Pharmacological Metabolism 11%
• Toxic 11%
• Chemistry 8%
• Carbon Atom 6%
• Amount 6%