Contrasting persistence strategies in Salmonella and Mycobacterium

Anna D. Tischler, John D. McKinney

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Long-term survival of persistent bacterial pathogens in mammalian hosts critically depends on their ability to avoid elimination by innate and adaptive immune responses. The persistent human pathogens that cause typhoid fever and tuberculosis exemplify alternative strategies for survival in the host: immune evasion and immune adaptation, respectively. Salmonella enterica serotype Typhi evades host innate immune responses and inflammation by expressing factors that interfere with its detection as a Gram-negative bacterium, enabling persistent colonization of an immunologically privileged niche, the gallbladder. In contrast, Mycobacterium tuberculosis has adapted to survive within phagocytic cells, which typically eliminate invading microbes, by deploying stress resistance mechanisms that counteract the harsh environment of the phagolysosome.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalCurrent Opinion in Microbiology
Issue number1
StatePublished - Feb 2010
Externally publishedYes

Bibliographical note

Funding Information:
ADT is supported by an Irvington Institute Postdoctoral Fellowship of the Cancer Research Institute. JDM acknowledges support from National Institutes of Health Grants AI046392 and HL088906.

Copyright 2010 Elsevier B.V., All rights reserved.

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