Contribution of the Actinobacteria to the growing diversity of lantibiotics

Xiulan Li; Daniel J. O'Sullivan

doi:10.1007/s10529-012-1024-2

Contribution of the Actinobacteria to the growing diversity of lantibiotics

Xiulan Li, Daniel J. O'Sullivan

Food Science and Nutrition

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Currently, 76 lantibiotics have been described; the vast majority being produced by members of the Firmicute phylum of bacteria. There is a growing number being identified from the Actinobacteria phylum and some of these exhibit novel modifications leading to an increased functional diversity among lantibiotics. In this review, we discuss the currently characterized lantibiotics highlighting the expanding diversity provided by those from the Actinobacteria. This increased diversity has the potential to expand lantibiotic applications as antimicrobials in foods and pharmaceuticals. In addition, a phylogenetic classification system based on the full prepropeptide sequences showed remarkable consistency with current classification systems and may provide a more rapid and convenient means for classifying lantibiotics.

Original language	English (US)
Pages (from-to)	2133-2145
Number of pages	13
Journal	Biotechnology Letters
Volume	34
Issue number	12
DOIs	https://doi.org/10.1007/s10529-012-1024-2
State	Published - Nov 2012

Bibliographical note

Funding Information:
Acknowledgments The Midwest Dairy Association (MDA) and Dairy Management Inc (DMI) are acknowledged for funding that contributed in part to this study.

Keywords

Actinobacteria
Bacteriocin
Bifidobacteria
Broad spectrum antimicrobial peptides
Lantibiotics

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Contribution of the Actinobacteria to the growing diversity of lantibiotics

Abstract

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Keywords

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