Control of the insect metamorphic transition by ecdysteroid production and secretion

Xueyang Pan; Robert P. Connacher; Michael B. O'Connor

doi:10.1016/j.cois.2020.09.004

Control of the insect metamorphic transition by ecdysteroid production and secretion

Xueyang Pan, Robert P. Connacher, Michael B. O'Connor

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Ecdysteroids are a class of steroid hormones that controls molting and metamorphic transitions in Ecdysozoan species including insects, in which ecdysteroid biosynthesis and its regulation have been extensively studied. Insect ecdysteroids are produced from dietary sterols by a series of reduction-oxidation reactions in the prothoracic gland and in Drosophila they are released into the hemolymph via vesicle-mediated secretion at the time of metamorphosis. To initiate precisely controlled ecdysteroid pulses, the prothoracic gland functions as a central node integrating both intrinsic and extrinsic signals to control ecdysteroid biosynthesis and secretion. In this review, we outline recent progress in the characterization of ecdysone biosynthesis and steroid trafficking pathways and the discoveries of novel factors regulating prothoracic gland function.

Original language	English (US)
Pages (from-to)	11-20
Number of pages	10
Journal	Current Opinion in Insect Science
Volume	43
DOIs	https://doi.org/10.1016/j.cois.2020.09.004
State	Published - Feb 2021
Externally published	Yes

Bibliographical note

Funding Information:
The authors thank MJ Shimell and Aidan Peterson for comments on the manuscript. This work was funded by a grant R35GM118029 from the National Institutes of Health to MBO. Support for R.C. was provided by National Institutes of Health, R01GM105707 to Aaron Goldstrohm.

Funding Information:
The authors thank MJ Shimell and Aidan Peterson for comments on the manuscript. This work was funded by a grant R35GM118029 from the National Institutes of Health to MBO. Support for R.C. was provided by National Institutes of Health, R01GM105707 to Aaron Goldstrohm.

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title = "Control of the insect metamorphic transition by ecdysteroid production and secretion",

abstract = "Ecdysteroids are a class of steroid hormones that controls molting and metamorphic transitions in Ecdysozoan species including insects, in which ecdysteroid biosynthesis and its regulation have been extensively studied. Insect ecdysteroids are produced from dietary sterols by a series of reduction-oxidation reactions in the prothoracic gland and in Drosophila they are released into the hemolymph via vesicle-mediated secretion at the time of metamorphosis. To initiate precisely controlled ecdysteroid pulses, the prothoracic gland functions as a central node integrating both intrinsic and extrinsic signals to control ecdysteroid biosynthesis and secretion. In this review, we outline recent progress in the characterization of ecdysone biosynthesis and steroid trafficking pathways and the discoveries of novel factors regulating prothoracic gland function.",

author = "Xueyang Pan and Connacher, {Robert P.} and O'Connor, {Michael B.}",

note = "Funding Information: The authors thank MJ Shimell and Aidan Peterson for comments on the manuscript. This work was funded by a grant R35GM118029 from the National Institutes of Health to MBO. Support for R.C. was provided by National Institutes of Health, R01GM105707 to Aaron Goldstrohm. Funding Information: The authors thank MJ Shimell and Aidan Peterson for comments on the manuscript. This work was funded by a grant R35GM118029 from the National Institutes of Health to MBO. Support for R.C. was provided by National Institutes of Health, R01GM105707 to Aaron Goldstrohm.",

year = "2021",

month = feb,

doi = "10.1016/j.cois.2020.09.004",

language = "English (US)",

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AU - Pan, Xueyang

AU - Connacher, Robert P.

AU - O'Connor, Michael B.

N1 - Funding Information: The authors thank MJ Shimell and Aidan Peterson for comments on the manuscript. This work was funded by a grant R35GM118029 from the National Institutes of Health to MBO. Support for R.C. was provided by National Institutes of Health, R01GM105707 to Aaron Goldstrohm. Funding Information: The authors thank MJ Shimell and Aidan Peterson for comments on the manuscript. This work was funded by a grant R35GM118029 from the National Institutes of Health to MBO. Support for R.C. was provided by National Institutes of Health, R01GM105707 to Aaron Goldstrohm.

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AB - Ecdysteroids are a class of steroid hormones that controls molting and metamorphic transitions in Ecdysozoan species including insects, in which ecdysteroid biosynthesis and its regulation have been extensively studied. Insect ecdysteroids are produced from dietary sterols by a series of reduction-oxidation reactions in the prothoracic gland and in Drosophila they are released into the hemolymph via vesicle-mediated secretion at the time of metamorphosis. To initiate precisely controlled ecdysteroid pulses, the prothoracic gland functions as a central node integrating both intrinsic and extrinsic signals to control ecdysteroid biosynthesis and secretion. In this review, we outline recent progress in the characterization of ecdysone biosynthesis and steroid trafficking pathways and the discoveries of novel factors regulating prothoracic gland function.

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Control of the insect metamorphic transition by ecdysteroid production and secretion

Abstract

Bibliographical note

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