Control of the yeast cell cycle with a photocleavable α-factor analogue

Laurie L. Parker; Josh W. Kurutz; Stephen B.H. Kent; Stephen J. Kron

doi:10.1002/anie.200602439

Control of the yeast cell cycle with a photocleavable α-factor analogue

Laurie L. Parker, Josh W. Kurutz, Stephen B.H. Kent, Stephen J. Kron

Biochemistry, Molecular Biology, and Biophysics (CBS)

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Under arrest: Photodegradation of a synthetic yeast α-factor analogue releases yeast from mating-factor-induced arrest into the cell cycle. This peptide has sufficient activity to arrest cells in G1 at reasonable doses and it can be specifically degraded through exposure to UV light at a wavelength that is "safe" for most cells. FITC-A = absorption of a fluorescein isothiocyanate analogue. (Graph Presented).

Original language	English (US)
Pages (from-to)	6322-6325
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	38
DOIs	https://doi.org/10.1002/anie.200602439
State	Published - Sep 25 2006

Keywords

Biotechnology
Peptides
Peptidomimetics
Pheromones
Receptors

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KW - Peptidomimetics

KW - Pheromones

KW - Receptors

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Control of the yeast cell cycle with a photocleavable α-factor analogue

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